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目的 探讨CD4 4v6在胃癌发生与发展中的作用。方法 运用免疫组化方法检测 2 4例浅表性胃炎、2 4例不典型增生胃粘膜、48例胃癌组织中CD4 4v6的表达。结果 ①浅表性胃炎组无CD4 4v6表达 ,不典型增生组和胃癌组CD4 4v6阳性率分别为 45 83%、5 0 0 0 % ,明显高于浅表性胃炎组 (P均 <0 0 1) ;②CD4 4v6表达与胃癌淋巴结转移和 pTNM分期有关 (P <0 0 5 ) ,与组织学类型无关 (P >0 0 5 )。结论 胃活检组织中CD4 4v6检测 ,有助于胃癌的早期诊断和淋巴结转移趋势的推测 ,并对预后的评估有一定价值
Objective To investigate the role of CD4 4v6 in the development and progression of gastric cancer. Methods Immunohistochemistry was used to detect the expression of CD4 4v6 in 24 cases of superficial gastritis, 24 cases of dysplasia of gastric mucosa, and 48 cases of gastric cancer. Results 1 There was no expression of CD4 4v6 in the superficial gastritis group. The positive rates of CD4 4v6 in the atypical hyperplasia group and the gastric cancer group were 45 83% and 500%, respectively, which were significantly higher than those in the superficial gastritis group (P<0.01). 2) The expression of CD4 4v6 was associated with lymph node metastasis and pTNM stage in gastric cancer (P < 0.05), but not with histological type (P > 0.05). Conclusion The detection of CD4 4v6 in gastric biopsy is helpful for the early diagnosis of gastric cancer and the speculation of lymph node metastasis, and it has a certain value in the evaluation of prognosis.