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用放免法检测25例新生儿肝炎综合征及23例对照组的血清25-羟D(25-OHD)浓度,前者8例肌注VitD10万U3周后复查。结果新生儿肝炎综合征患儿血清25-OHD明显下降,与对照组存在极显著差异(P<0.0001)。8例肌注VitD患儿中7例较治疗前上升,1例下降,均值与治疗前有显著性差异(P<0.0001)。提示新生儿肝炎综合征主要存在VitD吸收障碍,少数存在羟化障碍。
Serum 25-hydroxy D (25-OHD) concentrations in 25 cases of neonatal hepatitis syndrome and 23 cases of control group were detected by radioimmunoassay. The former 8 cases were intravitreally injected with VitD100 000 U3 weeks later. Results Serum 25-OHD in neonates with hepatitis syndrome decreased significantly compared with the control group (P <0.0001). Among 8 cases of intravitreal injection of VitD, 7 cases were increased before treatment and 1 case was decreased. There was significant difference between mean and before treatment (P <0.0001). Tip neonatal hepatitis syndrome exists mainly VitD absorption disorders, a few hydroxylation disorders.