万古霉素是一种糖肽抗生素,起初用于治疗青霉素耐药的革蓝氏阳性菌感染,有独特的疗效。后来,由于抗葡萄球菌的半合成青霉素和头孢菌素的引入,使万古霉素的应用日趋减少。最近,由于下列原因再度启用万古霉素:1.耐甲氧西林(Methicllin)葡萄球菌的感染频率增多了;2.对表皮葡萄球菌感染,特别是在分流术、导尿术和弥补性移植中感染的重要性有了更深一步的认识;3.已认识到艰难梭菌(Cl.difficile)是伪膜性结肠炎的病因;4.进行肾渗透的病人中,万古霉素的药代动力学较适宜。因此万古霉素受到肾病学家和临床医生的特别 Vancomycin is a glycopeptide antibiotic, initially used for the treatment of penicillin-resistant gram-positive bacteria infection, a unique effect. Later, due to the introduction of semi-synthetic penicillins and cephalosporins against staphylococci, the use of vancomycin was diminishing. Recently, vancomycin has been reinitiated for the following reasons: 1. An increased frequency of infections with methicillin-resistant staphylococci; 2. Staphylococcus epidermidis infections, especially in shunting, catheterization and make-up transplants 3. The importance of Cl.difficile has been recognized as the etiology of pseudomembranous colitis; 4. The pharmacokinetics of vancomycin in patients undergoing renal infiltration More appropriate. Vancomycin is therefore particularly special to nephrologists and clinicians