论文部分内容阅读
目的探讨血清脂肪酶亚型分析对胰腺炎(AP)及非胰腺炎脂肪酶升高的鉴别诊断价值。方法选取598例急性腹痛患者,分为AP组192例和非AP组406例,比较2组患者的一般资料,分析检测指标预测急性胰腺炎的受试者工作特征曲线下面积(AUROC),并采用多变量分析急性胰腺炎的预测指标。结果 AP组患者胰脂肪酶/总脂肪酶亚型值显著高于非AP组患者数据,差异有统计学意义(P<0.05);急性胰腺炎预测指标AUROC分析结果显示胰脂肪酶/总脂肪酶亚型差异具有统计学意义[95%CI(0.541,0.862),P=0.041],截断值为0.002 7,灵敏度和特异度分为83.3%和63.6%,阳性率和阴性率分别为55.6%和87.5%;多变量分析结果显示胰脂肪酶/总脂肪酶亚型(截断值为0.002 7时)与急性胰腺炎显著相关(P=0.022)。结论血清脂肪酶亚型分析能够很好区分AP及AR脂肪酶升高患者,对AP的诊断具有重要的临床意义。
Objective To investigate the differential diagnosis value of serum lipase subtype analysis on the increase of lipase in pancreatitis (AP) and non-pancreatitis. Methods A total of 598 patients with acute abdominal pain were selected and divided into two groups: 192 patients in AP group and 406 patients in non-AP group. The general data of two groups were compared. The AUROC of the index of predicting acute pancreatitis was analyzed. Multivariate analysis of predictors of acute pancreatitis. Results The pancreatic lipase / total lipase subtype in AP group was significantly higher than that in non-AP group (P <0.05). AUROC analysis showed that pancrelipase / total lipase The subtype difference was statistically significant (95% CI 0.541, 0.862, P 0.041) with a cutoff of 0.002 7, with a sensitivity and specificity of 83.3% and 63.6%, respectively. The positive and negative rates were 55.6% and 87.5%. Multivariate analysis showed that pancreatic lipase / total lipase subtype (cutoff of 0.002 7) was significantly associated with acute pancreatitis (P = 0.022). Conclusion Serum lipase subtype analysis can distinguish patients with elevated AP and AR lipase, and has important clinical significance for the diagnosis of AP.