【摘 要】
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Objective:Conversion of normal cells to cancer cells is often accompanied by abnormal synthesis of serum enzymes.Both alkaline phosphatase(ALP)and lactate dehydrogenase(LDH)have been reported to have prognostic value in a variety of malignancies.The aim o
【机 构】
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Department of Pancreatic-Biliary Surgery,Tongji Hospital,Tongji Medical College,Huazhong University
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Objective:Conversion of normal cells to cancer cells is often accompanied by abnormal synthesis of serum enzymes.Both alkaline phosphatase(ALP)and lactate dehydrogenase(LDH)have been reported to have prognostic value in a variety of malignancies.The aim of this study was to investigate the effect of preoperative serum ALP and LDH levels on the prognosis of patients with periampullary carcinoma who underwent pancreatoduodenectomy(PD).Methods:According to the preoperative ALP or LDH values,856 cancer patients receiving PD treatment from January 2001 to January 2019 were divided into high-ALP group and low-ALP group or high-LDH group and low-LDH group.Statistical analysis was carried out to study the differences between the high-ALP and low-ALP groups or the high-LDH and low-LDH groups.Furthermore,the possibility of preoperative ALP or LDH as prognostic factor of periampullary carcinoma was investigated.Results:In both the high-ALP and the high-LDH groups,the prognosis of patients with periampullary carcinoma who underwent PD was worse than that of the low-ALP and low-LDH group.Even through risk factor analysis,it was found that preoperative ALP and LDH could be independent prognostic factor for patients with periampullary carcinoma who underwent PD.Conclusion:Preoperative ALP or LDH is an independent risk factor for periampullary carcinoma.
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