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1 材料和方法 1.1 一般情况 基础疾病均为COPD,病程最短3年,最长37年。127例中男性78例,女性49例。男女之比为1.59:l。最小年龄26岁,最大年龄78岁。 1.2 方法 为除外细菌感染或趋于细菌感染的可能因素,制定了以下指标:(1)发病无脓性痰或发病前、后痰量、痰性质无明显变化;(2)血百分中WBC<1.1×10~9/L,NC<80％;(3)体温(腋温)低于37.5C;(4)胸部平片未见肺部感染的征象。获得符合上述各项指标的我院1989年1月～1990年12月间住院病例127例。对病例进行使用了抗生素治疗和未使用抗生素治疗分组。比较二组临床治愈率的差异,以分析COpD抗生素预防应用的意义。
1 Materials and Methods 1.1 General Conditions The underlying diseases are COPD, the shortest duration of 3 years, up to 37 years. There were 78 males and 49 females in 127 cases. The ratio of male to female is 1.59: l. The youngest 26 years old, the oldest is 78 years old. 1.2 Methods for excluding bacterial infection or the possible causes of bacterial infection, developed the following indicators: (1) the incidence of purulent sputum or sputum before and after the onset of sputum volume, no significant changes in the nature of sputum; (2) blood WBC percentage <1.1 × 10 ~ 9 / L, NC <80%; (3) body temperature (axillary temperature) less than 37.5C; (4) chest plain film no signs of pulmonary infection. Obtained in line with the above indicators of our hospital from January 1989 to December 1990 in-hospital cases of 127 cases. Cases were treated with antibiotics and without antibiotics. The difference between the two groups in clinical cure rate was compared in order to analyze the significance of COpD antibiotic prophylaxis.