脑组织病变常引起脑脊液的变化,常见细菌或病毒感染,但不同病原体所致的脑膜炎在发病早期临床表现相似,而及早确诊病原体是关键。脑脊液常规检测:微量蛋白、氯化物、葡萄糖和细胞计数;在细菌性脑膜炎早期,只有血细胞计数稍为增加,临床难于确认。我们在开展乳酸脱氢酶(LDH)、腺苷脱氨酶(ADA)及肌酸激酶(CK)等酶谱检测,发现LDH在细菌性脑膜炎的早期就升高明显,随病情的加重而不断上升,是诊断细菌性脑膜炎的早期病变较理想的标志物,在疾 Cerebral lesions often cause changes in cerebrospinal fluid, common bacterial or viral infections, but the meningitis caused by different pathogens in the early clinical manifestations of the disease similar to the early diagnosis of pathogens is the key. Cerebrospinal fluid routine testing: trace protein, chloride, glucose and cell count; in the early stages of bacterial meningitis, only a slight increase in blood cell count, clinically difficult to confirm. We carried out lactate dehydrogenase (LDH), adenosine deaminase (ADA) and creatine kinase (CK) and other zymograms detected and found LDH increased significantly in the early stage of bacterial meningitis, with the severity of the disease and Rising, is an ideal marker of early diagnosis of bacterial meningitis in disease