肿瘤细胞的浸润和转移是恶性肿瘤的标志性生物学行为,也是肿瘤始终难以攻克的最大障碍。乙酰肝素酶(heparanase,HPA)通过降解细胞外基质(ECM)中的硫酸乙酰肝素多聚糖蛋白和释放其结合的生长因子如碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)和各种酶等加速肿瘤浸润和新生血管形成这两个肿瘤发展的关键环节,从而促进肿瘤的浸润和转移。其基因的成功克隆和分子机制的深入研究为肿瘤治疗提供了新的方向。 The infiltration and metastasis of tumor cells are the hallmarks of malignant tumor biological behavior, but also the biggest obstacle tumor always difficult to overcome. Heparanase (HPA) is activated by degrading heparan sulfate proteoglycan in the extracellular matrix (ECM) and releasing its bound growth factors such as basic fibroblast growth factor (bFGF), vascular endothelial growth factor VEGF) and various enzymes to accelerate the tumor invasion and neovascularization of the two key aspects of tumor development, thereby promoting tumor invasion and metastasis. The successful cloning of its gene and further study of molecular mechanism provide a new direction for cancer treatment.