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缺氧的有害作用可能使心血管功能受损。大多数报导指出缺氧引起胎动脉压增加。关于缺氧是否导致胎血循环量改变,目前了解甚少。本文目的是探讨急性缺氧对胎循环血量的影响。作者将14只单胎妊娠的羊,在吸入麻醉下(1-2%halothane、40%氧和等量笑气),通过严格无菌过程将导管插入胎体。术后5～6天平均孕龄133±1(SE)天时进行试验。分为对照期、缺氧期和恢复期各30分钟。在母羊吸入的空气里加入氮和少量二氧化碳,造成缺氧。后者使胎仔维持稳定的二氧化碳张力。结果可见对照期胎仔动脉氧张力(Po_2)平均为22.3±0.7(SE)mmHg,在30分
The detrimental effects of hypoxia may impaired cardiovascular function. Most reports point out that hypoxia causes an increase in fetal arterial pressure. Little is known about whether hypoxia causes changes in the amount of fetal blood circulation. The purpose of this paper is to investigate the effect of acute hypoxia on fetal circulating blood volume. The authors inserted 14 singleton pregnant sheep into the carcass by a strictly sterile procedure under inhalation anesthesia (1-2% halothane, 40% oxygen and equal amount of nitrous oxide). The mean gestational age at 5 days to 6 days after operation was 133 ± 1 (SE). Divided into control period, hypoxia and recovery of 30 minutes each. Nitrogen and a small amount of carbon dioxide are added to the air inhaled by ewes, causing hypoxia. The latter keeps the fetus stable with carbon dioxide tension. The results showed that in the control period, the mean arterial oxygen tension (Po_2) was 22.3 ± 0.7 (SE) mmHg at 30 minutes