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目的:探讨血浆置换联合穴位注射治疗对重型肝炎患者肝纤维化指标的影响。方法:将收治的60例重型肝炎患者随机分为2组:A组29例,在常规内科治疗基础上配合血浆置换术;B组31例,在A组治疗基础上同时给予黄芪注射液足三里穴位注射治疗;观察两组患者治疗后血清透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PCⅢ)4项肝纤维化指标水平的变化情况,并与30例健康体检者(C组)比较。结果:治疗前A、B两组肝纤维化指标水平差异无统计学意义(P>0.05),但都高于C组(P<0.001);治疗后两组各项指标水平均下降,其中B组各项指标下降尤为显著,两组比较差异有统计学意义(P<0.05或P<0.001);B组治疗后与C组比较,Ⅳ-C、PCⅢ两项指标差异无显著性(P>0.05)。结论:血浆置换联合黄芪足三里穴位注射治疗能有效改善重型肝炎患者肝纤维化指标,从而改善患者预后。
Objective: To investigate the effect of plasma exchange combined with acupoint injection on liver fibrosis in patients with severe hepatitis. Methods: Sixty patients with severe hepatitis were randomly divided into two groups: group A (n = 29), with routine medical treatment and plasmapheresis; group B (n = 31), group A given Zusanli injection at the same time Point injection therapy was applied to observe the changes of four indexes of hepatic fibrosis indexes including serum hyaluronic acid (HA), laminin (LN), type Ⅳ collagen (Ⅳ-C) and type Ⅲ procollagen (PCⅢ) And compared with 30 healthy subjects (C group). Results: Before treatment, there was no significant difference between the two groups (P> 0.05), but both were higher than those in group C (P <0.001). After treatment, the levels of B (P <0.05 or P <0.001). Compared with group C, there was no significant difference of Ⅳ-C and PCⅢ between group B and group C (P> 0.05). Conclusion: Plasma exchange combined with astragalus injection of Zusanli points can effectively improve the indexes of liver fibrosis in patients with severe hepatitis and improve the prognosis of patients.