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目的探讨3D-多体素磁共振波谱(MRS)在评估脑胶质瘤手术切除程度的价值。方法对2011年6月-2012年4月32例脑胶质瘤患者术后行常规MRI及MRS检查,测定分析手术周边区域主要代谢产物N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)、Cho/NAA、Cho/Cr及NAA/Cr比值,对术后胶质瘤切除程度进行评价。同时通过术后病理检查结果评估肿瘤切除程度,再与MRS评估结果相比较。结果 32例中病理评估为9例全切除,23例为大部分切除;MRS评估为11例全切除,21例为大部分切除,评估结果与术后病理评估结果差异无统计学意义(P>0.05)。结论 MRS可以无创评价胶质瘤切除程度,为胶质瘤预后判定及进一步治疗提供了重要的依据。
Objective To investigate the value of 3D-multi-voxel magnetic resonance spectroscopy (MRS) in evaluating the degree of resection of glioma. Methods Thirty-two patients with glioma underwent routine MRI and MRS after operation from June 2011 to April 2012. The levels of major metabolites such as N-acetylaspartate (NAA), choline (Cho) ), Creatine (Cr), Cho / NAA, Cho / Cr and NAA / Cr ratio were measured. At the same time, the degree of tumor resection was evaluated by postoperative pathological examination, and then compared with MRS assessment. Results Of the 32 cases, 9 cases were completely resected and 23 cases were resected. MRS was performed in 11 cases and excision in 21 cases. There was no significant difference between the results of assessment and postoperative pathological evaluation (P> 0.05). Conclusion MRS can evaluate the degree of resection of glioma noninvasively and provide an important basis for prognosis and further treatment of glioma.