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目的:在女性有雌激素减少症状初期,补充小剂量雌激素,预防雌激素受体活性降低或数量减少,影响骨矿物质在骨组织的沉积以预防原发性骨质疏松发生。方法:对该院68例40岁以上有雌激素减少症状、查雌激素正常低限或减少、愿意接受雌激素治疗的女性,极早期、个体化、小剂量、周期性补充雌、孕激素。结果:雌、孕激素序贯治疗后,参与治疗者症状改善;女性激素水平较治疗前提高;脆性骨折发生率下降。结论:在有雌激素减少症状初期补充雌激素可防治中年女性原发性骨质疏松;正规使用雌激素不增加致癌风险。
OBJECTIVE: In the early stage of estrogen reduction in women, a small dose of estrogen is added to prevent the decrease or decrease of estrogen receptor activity, which may affect the deposition of bone mineral in the bone tissue to prevent the occurrence of primary osteoporosis. Methods: The hospital 68 cases of estrogen over 40 years to reduce the symptoms, check the normal low limit or decrease in estrogen, women willing to accept estrogen treatment, very early, individualized, low-dose, periodic replacement of estrogen and progesterone. Results: After sequential treatment of estrogen and progesterone, the symptoms of participating patients improved; the level of female hormone was higher than that before treatment; and the incidence of brittle fracture was decreased. CONCLUSIONS: Estrogen supplementation may prevent primary osteoporosis in middle-aged women when initial estrogen-lowering symptoms are present; regular use of estrogen does not increase the carcinogenic risk.