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目的 探讨失血性低血容量休克病人血浆一氧化氮 (NO)浓度与预后的关系。方法 2 0 0 1年 7月至2 0 0 2年 1月 ,应用比色法测定 2 9例失血性低血容量休克病人血浆NO浓度 ,与 2 0例择期手术病人进行对照 ,观察NO与多器官功能障碍综合征 (MODS)的关系。结果 休克组血浆NO浓度 ( 74 2± 46 9) μmol/L ,较对照组( 5 0 5± 2 3 3 ) μmol/L明显升高 (P <0 0 5 )。休克组发生MODS病人血浆NO浓度 ( 90 4± 5 3 5 ) μmol/L ,较未发生MODS者血浆NO浓度 ( 5 4 2± 2 7 9) μmol/L明显升高 (P <0 0 5 )。 结论 失血性低血容量休克NO产生过多可能参与MODS的发生
Objective To investigate the relationship between plasma nitric oxide (NO) concentration and prognosis in patients with hemorrhagic hypovolemic shock. Methods From July 2001 to January 2002, 29 patients with hemorrhagic hypovolemic shock were assayed by colorimetric method for the determination of plasma NO levels, compared with 20 patients undergoing elective surgery, and NO and Organ dysfunction syndrome (MODS) relationship. Results Plasma NO concentration in the shock group was significantly higher (74 2 ± 46 9) μmol / L than that in the control group (50 ± 2 3 3) μmol / L (P 0 05). Plasma NO concentration in MODS patients (904 ± 535) μmol / L in shock group was significantly higher than that in non-MODS patients (542 ± 297 μmol / L) (P <0.05) . Conclusions Excessive NO production in hemorrhagic hypovolemic shock may be involved in the pathogenesis of MODS