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目的:比较常规血液透析(HD)和血液透析滤过(HDF)两种血液净化方式对维持性血液透析患者微炎症状态的影响。方法:入选50例维持性血液透析患者随机分为对照组HD组(n=25)和治疗组HDF组(n=25)。比较入组时、单次透析后及透析3个月后血清高敏C反应蛋白(high-sensitivity C-reactive protein Hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)的水平变化,并比较各组间是否存在差别。结果:入组时、单次透析后Hs-CRP、IL-6、TNF-α水平差异无统计学意义(P>0.05),3月后血液透析滤过组Hs-CRP、IL-6、TNF-α水平治疗后较治疗前显著降低(P<0.05);透析组治疗后上述指标较治疗前略升高,差异无显著性意义(P>0.05)。结论:采用HDF可以降低MHD患者的血清Hs-CRP、IL-6、TNF-α水平,显著改善微炎症状态。
Objective: To compare the effects of conventional hemodialysis (HD) and hemodiafiltration (HDF) on the micro-inflammatory status of maintenance hemodialysis patients. Methods: Fifty patients with maintenance hemodialysis were randomly divided into control group HD group (n = 25) and treatment group HDF group (n = 25). When compared with the control group, the levels of serum high-sensitivity C-reactive protein Hs-CRP, IL-6 and TNF -α) level changes, and compare the differences between the groups. Results: There were no significant differences in Hs-CRP, IL-6 and TNF-α levels after single dialysis (P> 0.05) -α levels were significantly lower than those before treatment (P <0.05). The above indexes in dialysis group were slightly higher than those before treatment, with no significant difference (P> 0.05). Conclusion: HDF can reduce the levels of serum Hs-CRP, IL-6 and TNF-α in MHD patients and significantly improve the micro-inflammation status.