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目的:探讨高危型人乳头状瘤病毒(HPV)DNA检测与液基细胞学检查(TCT)在子宫颈病变诊断中的应用价值。方法:对600例患者分别做HPV-DNA和TCT检测,对其中一项或两项异常者做阴道镜病理活检,对病理结果阳性患者进行HPV-DNA和TCT检测结果分析。结果:其中一项或两项异常者150例,HPV-DNA检测阳性者(H组)为115例,其中病理结果阳性为39例,符合率为33.9%;TCT检测阳性者(T组)为76例,其中病理结果阳性为40例,符合率为33.9%;两项均为阳性者(H+T组)是56例,其中病理结果阳性为51例,符合率为91.1%。H组与H+T组比较x2=13.95,P<0.01;T组与H+T组比较x2=4.00,P<0.05,结果有显著差异。结论:HPV-DNA及TCT联合起来进行检测可以提高宫颈癌及癌前病变的筛查及早期诊断的检出率。
Objective: To investigate the value of high-risk human papillomavirus (HPV) DNA testing and liquid-based cytology (TCT) in the diagnosis of cervical lesions. Methods: HPV-DNA and TCT were detected in 600 patients. Colposcopy biopsy was performed on one or both of them. The results of HPV-DNA and TCT were analyzed in patients with positive pathology. Results: Among 150 cases with one or two abnormalities, 115 cases were positive for HPV-DNA test (group H), of which 39 cases were pathologically positive, the coincidence rate was 33.9%. The TCT positive patients (T group) were Among 76 cases, the pathological results were positive in 40 cases and the coincidence rate was 33.9%. In both cases, H + T group was 56 cases, of which pathological results were positive in 51 cases and the coincidence rate was 91.1%. H group and H + T group compared x2 = 13.95, P <0.01; T group and H + T group compared x2 = 4.00, P <0.05, the results were significantly different. Conclusion: Combined detection of HPV-DNA and TCT can improve the detection rate of cervical cancer and precancerous lesions screening and early diagnosis.