论文部分内容阅读
目的:探讨各期妊娠期及各年龄段母体25-(OH)D及甲状腺激素的水平,并了解二者间的相关性。方法:选取2014年8月至2015年7月既往无甲状腺相关疾病史的妊娠孕妇1 029名。所有孕妇按孕周分为孕早期组(0~12+6周)、孕中期组(13~27+6周)、孕晚期组(28周~分娩);按年龄分为A组(<25岁)、B组(≥25岁而≤30岁)、C组(>30岁)。运用串联质谱仪检测维生素D水平,甲状腺相关激素由全自动电化学发光免疫分析仪完成测定。结果:25-(OH)D和甲状腺激素水平在各年龄组间差异无统计学意义(P>0.05),而25-(OH)D水平随着年龄升高呈升高的趋势。25-(OH)D水平随着孕期增加而升高,差异有统计学意义(P<0.05),孕妇在不同妊娠期血清25-(OH)D营养缺乏情况普遍存在,组间比较差异有统计学意义(P<0.05);FT3、FT4随着孕期增加而降低,而TSH水平孕中期及孕晚期明显升高,差异均有统计学意义(P<0.05)。25-(OH)D与甲状腺激素间无相关性(P>0.05)。结论:孕妇妊娠阶段与25-(OH)D及甲状腺激素水平密切相关,甲状腺激素水平与25-(OH)D无相关,孕妇普遍存在25-(OH)D不足或缺乏。
Objective: To investigate the levels of maternal 25- (OH) D and thyroid hormones during pregnancy and all stages of pregnancy, and to understand the correlation between them. Methods: A total of 1,029 pregnant women with no history of thyroid-related diseases from August 2014 to July 2015 were selected. All pregnant women were divided into three groups according to gestational age: first trimester group (0-12 + 6 weeks), second trimester group (13-27 + 6 weeks) and third trimester group (28 weeks- delivery) Years old), group B (≥25 years and ≤30 years old), group C (> 30 years old). Using tandem mass spectrometry to detect vitamin D levels, thyroid-related hormones were measured by an automated chemiluminescence immunoassay analyzer. Results: The levels of 25- (OH) D and thyroid hormones had no significant difference among all age groups (P> 0.05), while the level of 25- (OH) D increased with age. The level of 25- (OH) D increased with the increase of pregnancy, the difference was statistically significant (P <0.05). The pregnant women had ubiquitous serum 25- (OH) D deficiency in different gestation periods (P <0.05). FT3 and FT4 decreased with the increase of pregnancy, while TSH levels increased significantly in the second trimester and the third trimester. The differences were statistically significant (P <0.05). No correlation was found between 25- (OH) D and thyroid hormones (P> 0.05). CONCLUSION: Pregnant women are closely related to the level of 25- (OH) D and thyroid hormone during pregnancy. The level of thyroid hormone is not related to 25- (OH) D. Pregnant women are generally deficient or deficient in 25- (OH) D.