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为探讨抗利尿激素 (ADH)和原发性遗尿症 (PNE)发病的相关性 ,用放免法测定PNE患儿和健康正常儿童的白天及夜间血浆ADH水平 ,并测定同时点的血和尿渗透压。结果表明 ,正常对照组凌晨1时的ADH水平明显升高 ,达87.79ng/L±22.45ng/L ,较下午3时ADH水平 (55.49ng/L±15.97ng/L)上升了58.2 % ,差异具有显著性 (P<0.001) ;病例组在凌晨1时和下午3时ADH水平分别为59.11ng/L±35.45ng/L和66.84ng/L±42.82ng/L ,差异无显著性 (P>0.05) ;与正常对照组相比 ,病例组在下午3时的ADH水平差异无显著性 (P>0.05) ,而凌晨1时则明显降低 (P<0.001)。提示广东地区健康儿童夜间ADH分泌明显升高 ,而PNE患儿没有发现夜间ADH分泌高峰 ,即广东地区PNE患儿的发病与夜间ADH分泌不足有关
To investigate the correlation between antidiuretic hormone (ADH) and primary enuresis (PNE), the levels of ADH in day and night were measured by radioimmunoassay in children with PNE and healthy children, and the simultaneous blood and urine permeation Pressure The results showed that the ADH level in the normal control group was significantly increased at 1 am (87.79 ng / L ± 22.45 ng / L), which was 58.2% higher than that at 3 pm (55.49 ng / L ± 15.97 ng / L) (P <0.001). The ADH levels in case group were 59.11ng / L ± 35.45ng / L and 66.84ng / L ± 42.82ng / L at 1:00 am and 3:00 pm, respectively, with no significant difference (P> 0.05). Compared with the normal control group, there was no significant difference in the level of ADH at 3:00 PM in the case group (P> 0.05) and at 1:00 PM (P <0.001). Suggesting that healthy children in Guangdong at night ADH secretion was significantly increased, while PNE children did not find the peak night ADH secretion, that is, the incidence of PNE in Guangdong area with the lack of ADH secretion at night