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目的 研究非小细胞肺癌CD4 4v6和C erbB 2基因蛋白的表达状况及其临床意义。方法 应用链霉菌抗生物素蛋白 过氧化物酶 (SP)法染色技术 ,对 6 5例非小细胞肺癌组织标本进行检测 ,并分析其临床意义。结果 CD4 4v6高表达与非小细胞肺癌的淋巴结转移及临床分期有关 (P <0 0 5) ;C erbB 2高表达与非小细胞肺癌的淋巴结转移有关 (P <0 0 5)。结论 检测CD4 4v6和C erbB 2基因蛋白的表达 ,有可能为判断非小细胞肺癌淋巴结转移、病变的发展以及评估预后提供依据
Objective To investigate the expression of CD4 4v6 and C erbB 2 protein in non-small cell lung cancer and its clinical significance. Methods Sixty-five non-small cell lung cancer samples were detected by streptavidin-peroxidase (SP) staining and their clinical significance was analyzed. Results The high expression of CD4 4v6 was associated with lymph node metastasis and clinical stage in non-small cell lung cancer (P <0.05). The high expression of C erbB 2 was associated with lymph node metastasis in non-small cell lung cancer (P <0.05). Conclusion Detecting the expression of CD4 4v6 and C erbB 2 gene may provide a basis for judging the lymph node metastasis, pathological changes and prognosis of non-small cell lung cancer