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目的探讨耐多药结核杆菌对二线抗结核药物的敏感性。方法选取2012年6月-2015年3月我院收治的结核感染复治患者44例的临床资料。将44株对异烟肼和利福平耐药的阳性结核菌株,复苏接种到罗氏培养基上,培养25 d。观察患者耐多药结核菌对不同二线抗结核单种药物敏感情况和多种药物敏感情况。结果 44株耐多药结核分枝杆菌对CPM、AMK、LOF、PAS的敏感率依次为72.73%、90.91%、63.64%、45.45%。结论所纳入研究者对PAS敏感度较低,对CPM、AMK、LOF已表现出一定的耐药性,临床需引起足够的重视。
Objective To investigate the susceptibility of multidrug-resistant Mycobacterium tuberculosis to second-line anti-TB drugs. Methods The clinical data of 44 patients with tuberculosis complicated with infection treated in our hospital from June 2012 to March 2015 were selected. Forty-four positive TB strains resistant to isoniazid and rifampicin were resuscitated and inoculated on Roche medium for 25 days. To observe the patients with multi-drug resistant Mycobacterium tuberculosis to different second-line anti-tuberculosis single drug sensitivity and multi-drug sensitivity. Results The sensitivity rates of 44 multidrug - resistant Mycobacterium tuberculosis to CPM, AMK, LOF and PAS were 72.73%, 90.91%, 63.64% and 45.45%, respectively. Conclusions The included investigators are less sensitive to PAS and have shown some resistance to CPM, AMK and LOF. Clinicians should pay enough attention to it.