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目的:探讨乙肝后肝硬化血瘀证与血清IP-10含量及转氨酶水平的相关性。方法:观察并分析血清IP-10含量及相关血清学指标与乙肝后肝硬化血瘀证之间的联系。结果:120例乙肝后肝硬化患者中,中医宏观辨证血瘀证组以舌质紫暗最常见,占56例(93.33%),次为面色晦暗、黧黑47例(78.33%),舌瘀点瘀斑41例(68.33%),脉细涩36例(60%);乙肝后肝硬化血瘀证组,非血瘀证组在AST、ALT、LN、IV-C、PCⅢ无统计学意义,非血瘀证组与血瘀证组比较,HA水平均低于血瘀证组(P<0.01),血瘀证组与HA、IP-10含量呈现正相关关系;乙肝后肝硬化失代偿期血瘀证与代偿期血瘀证组与IP-10无统计学意义(P>0.05%)。结论:乙肝后肝硬化患者血瘀证与HA、IP-10的含量有关,中医宏观辨证与现代医学微观辨证相结合更有利于揭示血瘀证的实质。
Objective: To investigate the correlation between the blood stasis syndrome of hepatitis B cirrhosis and serum IP-10 and the level of aminotransferase. Methods: The relationship between serum IP-10 levels and related serological markers and post-hepatitis B cirrhosis with blood stasis syndrome was observed and analyzed. Results: Of 120 patients with posthepatitic cirrhosis, the most common type of dark purple tongue was blood stasis syndrome in TCM syndrome group (56 cases, 93.33%), followed by dull complexion (47 cases, 78.33%), tongue petechia 41 cases (68.33%) and 36 cases (60%) of ecchymosis were found in ecchymosis; there was no statistical significance in AST, ALT, LN, IV-C and PCⅢ in patients with posthepatitic cirrhosis and blood stasis syndrome, Compared with blood stasis syndrome group, HA levels in non-blood stasis syndrome group were lower than that in blood stasis syndrome group (P <0.01), and blood stasis syndrome group was positively correlated with HA and IP-10 content; Period of blood stasis syndrome and compensatory blood stasis syndrome group and IP-10 had no statistical significance (P> 0.05%). Conclusion: The blood stasis syndrome in patients with posthepatitic cirrhosis is related to the contents of HA and IP-10. The combination of TCM syndrome differentiation with modern medical micro-differentiation is more conducive to reveal the essence of syndrome of blood stasis.