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目的 探讨酒石酸对胶囊制剂中碱性辅料的掩蔽效果。方法 用酒石酸做掩蔽剂 ,用非水滴定法对诺氟沙星胶囊进行含量测定。结果 平均回收率为 99 8%,RSD为 0 2 %。结论 酒石酸对胶囊制剂中碱性辅料具有掩蔽作用 ,能消除碱性辅料对测定结果的干扰 ,方法简便 ,结果准确 ,重现性好。
Objective To investigate the masking effect of tartaric acid on the alkaline excipients in capsule preparations. Methods tartaric acid as a masking agent, non-aqueous titration of norfloxacin capsules were determined. Results The average recovery was 99.8% with RSD of 0.2%. Conclusion Tartaric acid has a masking effect on the alkaline excipients in the capsule preparation, and can eliminate the interference of the alkaline excipients on the determination results. The method is simple, the method is accurate, and the reproducibility is good.