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目的:探讨氨甲蝶呤(MTX)单次肌注与分次肌注治疗输卵管妊娠的疗效。方法:将血β-hCG<6000mIU/ml,包块直径<5cm,要求保守治疗的64例异位妊娠患者随机分组,分为单次肌注组36例,分次肌注组28例。结果:两组均于治疗后第8天血β-hCG开始明显下降,与治疗前比较差异显著(P<0.05);两组治疗前后包块消失时间分别为16～98天,20～62天,两组无显著性差异;两组成功率比较无显著性差异。结论:氨甲蝶呤单次肌注治疗输卵管妊娠是一种可行的新方法,较其他保守治疗有一定的优越性,并且安全、经济、疗效好,副作用小,而且不影响生育功能。
Objective: To investigate the efficacy of methotrexate (MTX) single intramuscular injection and intramuscular injection in the treatment of tubal pregnancy. Methods: Sixty-four patients with ectopic pregnancy requiring conservative treatment of β-hCG <6000mIU / ml and mass diameter <5cm were randomly divided into a single intramuscular group of 36 cases and a group of intramuscular injection of 28 cases. Results: The blood β-hCG levels in the two groups decreased significantly on the 8th day after treatment, with significant difference compared with those before treatment (P <0.05). The disappearance time of the two groups before and after treatment were 16-98 days, 20-62 days , No significant difference between the two groups; no significant difference in the success rate between the two groups. Conclusion: The single intramuscular injection of methotrexate for tubal pregnancy is a feasible new method, which has some advantages over other conservative treatments. It is safe, economical, effective and has few side effects. It does not affect fertility function.