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目的:研究胃乐冲剂对大鼠慢性萎缩性胃炎的作用与机制。方法:以2%的水杨酸钠和30%的酒精的混合溶液对大鼠进行灌胃复制慢性萎缩性胃炎大鼠。测定胃液酸度、胃蛋白酶活性和血中胃泌素、cAMP、cGMP含量;并观察对小鼠胃肠推进功能的影响和抗炎镇痛作用。结果:胃乐冲剂明显增加游离酸、总酸度、胃蛋白酶活性,降低PH值,增加cAMP含量,降低cGMP、胃泌素含量;可加快小鼠小肠推进速度,并有一定的抗炎镇痛作用。结论:胃乐冲剂能明显改善模型大鼠的胃内环境,增强消化功能、有明显的保护胃粘膜作用,并可增强胃肠功能,有一定的抗炎镇痛作用。
Objective: To study the effect and mechanism of Weile Granules on chronic atrophic gastritis in rats. METHODS: Rats were chronically atrophic gastritis with gavage of 2% sodium salicylate and 30% alcohol. Gastric acidity, pepsin activity, and blood gastrin, cAMP, cGMP levels were measured; effects on gastrointestinal propulsion and anti-inflammatory and analgesic effects in mice were also observed. Results: Weile Granules significantly increased free acid, total acidity, pepsin activity, decreased PH value, increased cAMP content, decreased cGMP, gastrin content, accelerated speed of small intestinal intestine, and had certain anti-inflammatory and analgesic effects. . Conclusion: Weile Granules can obviously improve the gastric environment of model rats, enhance digestive function, have obvious protective effect on gastric mucosa, and can enhance gastrointestinal function, and have certain anti-inflammatory and analgesic effects.