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目的 :分析乳腺导管内乳头状瘤癌变患者的临床病理特征及治疗和生存情况。方法 :回顾性分析1998年11月—2011年7月本院收治的151例乳腺导管内乳头状瘤癌变患者的病历资料和随访资料。根据病理诊断结果,将这151例患者分成癌变局限于导管内113例(74.8%)和癌变伴浸润38例(25.2%)。分析这些患者的临床病理特征及治疗和生存情况。结果 :癌变伴浸润患者发生乳头溢液的比例更高(P=0.036)。癌变伴浸润患者的Ki-67表达水平高于癌变局限于导管内患者(P=0.006);3年和5年无病生存率差异均无统计学意义(P>0.05)。结论 :癌变伴浸润患者的乳头溢液发生率较高,Ki-67表达水平也较高。早期发现和早期诊断对乳腺导管内乳头状瘤癌变患者的治疗和预后均有重要意义。
Objective: To analyze the clinicopathological characteristics, treatment and survival of patients with intraductal papillomatosis. Methods: The clinical data and follow-up data of 151 breast cancer patients with intraductal papilloma who had been treated in our hospital from November 1998 to July 2011 were retrospectively analyzed. According to the results of pathological diagnosis, the 151 patients were divided into cancers limited to 113 cases (74.8%) in duct and 38 cases (25.2%) with canceration and infiltration. The clinical and pathological features and treatment and survival of these patients were analyzed. Results: The rate of nipple discharge was higher in patients with cancerous and infiltrating infiltration (P = 0.036). The expression of Ki-67 in cancerous patients with infiltration was higher than that in cancerous patients (P = 0.006). There was no significant difference in the 3-year and 5-year disease-free survival rates (P> 0.05). Conclusions: The incidence of nipple discharge in patients with cancerous and infiltrating patients is high, and the expression of Ki-67 is also higher. Early detection and early diagnosis of breast ductal carcinoma in patients with cancer treatment and prognosis are of great significance.