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内皮素是新近发现的一种强有力的血管收缩肽,近来已从人和猪的内皮细胞培养液中分离得到。内皮素对各种血管床具有强烈的血管收缩作用,并导致前列环素和内皮衍化松弛因子的释放。实验证实,羊内毒素血症时,其血浆和肺淋巴中内皮素-1样免疫活性物质(内皮素-1-LI)浓度增加,而正常羊则无此现象,其原因可能系内毒素诱导内皮细胞受损所致。有迹象表明,内皮素参与了急性心肌梗塞、尿毒症的发病机理,本文测定了脓毒症患者血浆内皮
Endothelin is a newly discovered potent vasoconstrictor peptide that has recently been isolated from human and porcine endothelial cell cultures. Endothelin has a strong vasoconstrictor effect on various vascular beds and leads to the release of prostacyclin and endothelium-derived relaxing factor. Experiments have shown that endotoxin-1-like immunoreactive substances (endothelin-1-LI) are present in plasma and lung lymph vessels in sheep with endotoxemia but not in normal sheep, which may be due to endotoxin-induced Damage caused by endothelial cells. There are indications that endothelin is involved in the pathogenesis of acute myocardial infarction, uremia, this paper measured the plasma endothelium in patients with sepsis