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目的探讨症状性脑动脉狭窄患者支架置入及药物治疗对疾病预后的影响。方法符合入选标准的240例症状性脑动脉狭窄患者按治疗方法不同分为支架置入组(n=113)和药物治疗组(n=127),支架置入组进行脑动脉狭窄支架置入治疗,药物治疗组单纯应用药物治疗;观察疗效并随访12个月,观察短暂性脑缺血发作(TIA)或新发脑梗死发生率。结果支架置入组患者均成功置入支架,但2例围手术期合并脑出血,1例病情加重死亡,1例痊愈,术后随访112例有9例(8.04%)发生与原狭窄动脉供血区相关的轻微卒中;药物治疗组患者随访127例再发卒中27例(21.26%),差异有统计学意义(P<0.01)。结论症状性脑动脉狭窄患者在药物治疗基础上行支架置入治疗安全、有效,与单纯药物治疗相比,能显著改善短期内的临床预后。
Objective To investigate the influence of stenting and drug therapy on the prognosis of patients with symptomatic cerebral artery stenosis. Methods A total of 240 patients with symptomatic cerebral arterial stenosis who met the inclusion criteria were divided into three groups according to different treatment methods: n = 113 and drug treatment group (n = 127). Stent implantation group was treated with stenting of cerebral artery stenosis The drug treatment group was treated with drug only. The curative effect was observed and followed up for 12 months. The incidence of transient ischemic attack (TIA) or new-onset cerebral infarction was observed. Results All the patients in the stent group were successfully placed in the stent. However, 2 patients underwent perioperative intracranial hemorrhage. One patient died of aggravating disease and one patient recovered. There were 9 cases (8. (P <0.01). There were 27 cases (21.26%) of 127 recurrent stroke patients in the drug treatment group, the difference was statistically significant (P <0.01). Conclusions Patients with symptomatic cerebral artery stenosis are safe and effective in stenting on the basis of medical treatment. Compared with the simple drug treatment, they can significantly improve the short-term clinical prognosis.