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目的 研究米索前列醇〔前列腺E1(PGE1)类似物〕对切除卵巢雌性大鼠骨质疏松的影响及作用机制。 方法 应用切除卵巢大鼠的骨质疏松模型 ,随机分为治疗前组、对照组、低剂量组、高剂量组、假手术组 (每组 10只 ) ,给予不同剂量的米索前列醇后 ,以双能X线吸收法测定骨密度(BMD)、血清骨钙素 (BGP)及尿羟脯氨酸与肌酐比值 (HOP/Cr) ,并进行组间比较。 结果 米索前列醇治疗组的BMD〔(0 2 6± 0 0 3)g/cm2 和 (0 2 8± 0 0 2 )g/cm2 〕明显高于对照组〔(0 2 3± 0 0 2 )g/cm2 ,P <0 0 5〕 ;高剂量治疗组的BMD接近假手术组〔(0 30± 0 0 1)g/cm2 〕(P >0 0 5 ) ;治疗组的血清BGP〔(3 85± 0 5 6 ) μg/L和 (4 36± 0 6 2 ) μg/L〕明显高于对照组〔(3 0 2± 0 4 2 ) μg/L ,P <0 0 5〕 ;尿HOP/Cr治疗组〔(31 2 7± 6 4 4 )mg/g和 (2 8 5 2± 6 5 6 )mg/g〕与对照组〔(2 9 76± 5 82 )mg/g〕差异无显著性(P >0 0 5 )。 结论 米索前列醇对骨质疏松模型鼠有增加骨量的作用 ,且主要影响骨形成环节
Objective To investigate the effect of misoprostol (PGE1) on osteoporosis in female ovariectomized rats and its mechanism. Methods Osteoporosis model of ovariectomized rats was randomly divided into treatment group, control group, low dose group, high dose group and sham operation group (10 rats in each group). After given different doses of misoprostol, Bone mineral density (BMD), serum BGP and urinary hydroxyproline to creatinine ratio (HOP / Cr) were determined by dual-energy X-ray absorptiometry and compared between groups. Results BMD [(0 2 6 ± 0 0 3) g / cm 2 and (0 2 8 ± 0 0 2) g / cm 2] in the misoprostol treatment group was significantly higher than that in the control group [(0 2 3 ± 0 0 2 ) g / cm2, P <0.05). The BMD of the high-dose treatment group was close to that of the sham operation group (0 30 ± 0 0 1 g / cm2〕 (P 0 05) 3 85 ± 0 5 6) μg / L and (4 36 ± 0 6 2) μg / L] were significantly higher than those in the control group [(3 0 2 ± 0 4 2) μg / L, P 0 05) The difference between the HOP / Cr group and the control group [(31 2 7 ± 6 4 4) mg / g and (2 8 5 2 ± 6 5 6) mg / g] No significant (P> 0.05). Conclusion Misoprostol has the effect of increasing bone mass in osteoporosis model rats and mainly affects the bone formation