弹性蛋白酶是一种肽链内切酶,具有水解弹性蛋白的功能。目前研究表明,弹性蛋白酶可调节脂质代谢,降低血甘油三酯和胆固醇,升高高密度脂蛋白,可有效治疗高脂血症和脂肪性肝痛。并且发现, 弹性蛋白酶的活性与肝纤维化的进程有关。此文就弹性蛋白酶在高脂血症、脂肪性肝病和肝纤维化治疗中的应用进展作一综述。 Elastase is an endopeptidase that has the function of hydrolyzing elastin. The current study shows that elastase can regulate lipid metabolism, lower blood triglycerides and cholesterol, increased high-density lipoprotein, which can effectively treat hyperlipidemia and fatty liver pain. And found that the activity of elastase and liver fibrosis process. This article reviews the progress of elastase in the treatment of hyperlipidemia, fatty liver disease and liver fibrosis.