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患者女,18岁,因面色苍白24天,发热咽痛10天入院。患者于24天前出现面色苍白,并进行性加重,伴头晕、乏力,10天前出现发热,体温波动在38～39℃,伴咽痛。在当地医院拟诊为再生障碍性贫血(AA)。给康力龙、生白能、丙种球蛋白及抗炎对症支持治疗,病情无好转。追问病史,患者2个月前查体发现HBsAg(+)、HBeAg(+)、抗-HBcIgG(+)、ALT398U,诊断为慢性乙型肝炎活动期,并于1个月前开始皮下注射干扰素300IU,1次/d,14天后改为1次/2d,共用17次。用药前外周血:WBC6.9×10~9/L,HGB88g/L,PLT291×
Female patient, 18 years old, pale for 24 days, fever, sore throat 10 days admitted. Patients appeared pale and progressive 24 days ago, with dizziness, fatigue, fever occurred 10 days ago, body temperature fluctuations in the 38 ~ 39 ℃, with sore throat. In the local hospital to be diagnosed with aplastic anemia (AA). To ConLong, raw white, gamma globulin and anti-inflammatory symptomatic supportive treatment, the condition did not improve. Questioning the medical history, we found HBsAg (+), HBeAg (+), anti-HBcIgG (+) and ALT398U 2 months ago. The patients were diagnosed as active chronic hepatitis B and started subcutaneous injection of interferon 1 month ago 300IU, 1 time / d, 14 days later changed to 1 / 2d, a total of 17 times. Peripheral blood before treatment: WBC6.9 × 10 ~ 9 / L, HGB88g / L, PLT291 ×