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以磷脂脂质体模拟血液细胞,用1,6二苯基已三烯(DPH)为荧光探针,荧光偏振法研究了安络血、止血芳酸、维生素K1和6氨基已酸4种止血剂作为客体分子与脂质体及血液红细胞两类主体分子互相作用而形成的超分子化合物。利用偏振度(P)与微粘度(η)的定量关系,计算微粘度的变化,并以微粘度的变化推测止血剂与红细胞的作用机制。结果表明,止血剂与脂质体或血红细胞的相互作用力主要是超分子作用力。不同血凝机制的止血剂与红细胞作用方式也不尽相同。本文还对止血剂与红细胞的结合方式进行了探讨。
Phospholipid liposomes were used to simulate blood cells. Fluorescence polarization method was used to study the effect of antihypertensive acid, vitamin K1 and 6-aminocaproic acid Hemostatic agents as guest molecules and liposomes and red blood cells of the two main molecules interact to form a supramolecular compound. Using the quantitative relationship between the degree of polarization (P) and the microviscosity (η), the change of microviscosity was calculated, and the mechanism of the action of hemostatic agent and erythrocyte was deduced from the change of microviscosity. The results show that the interaction between hemostatic agents and liposomes or red blood cells is mainly supramolecular force. Different hemostatic mechanism of hemostatic and erythrocyte role of the way are not the same. This article also on the hemostatic agents and the way of red blood cells were discussed.