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近来已有报告γ干扰素-(IFN-γ)可作为慢性肉芽肿病患者的抗细菌和真菌感染的预防性用药,IFN-γ联合乙胺嘧啶可用于治疗艾滋病患者的大脑内鼠弓形体病复发,然而,外源性IFN-γ对实验性隐球菌病病程的影响尚无报道.为此,作者研究了单用免重组γ干扰素(rIFN-γ)或联合低剂量两性霉素B治疗实验性BACB/C鼠隐球菌病的体内活性及rIFN-γ对受感染鼠脾的α肿瘤坏死因子(TNF-α)的影响.
It has recently been reported that interferon- (IFN- [gamma]) can be used as a prophylactic drug against bacterial and fungal infections in patients with chronic granulomatous disease and that IFN- [gamma] in combination with pyrimethamine can be used to treat murine toxoplasmosis However, the effect of exogenous IFN-γ on the course of experimental cryptococcal disease has not been reported, and for this reason, the authors studied whether treatment with rIFN-γ alone or in combination with low-dose amphotericin B In vivo activity of experimental BACB / C murine cryptococcosis and effect of rIFN-γ on α-tumor necrosis factor (TNF-α) in spleen of infected mice.