1例45岁男性患者因反酸给予雷贝拉唑钠肠溶片10 mg,1次/d。3周后因症状加重自行加倍服药。3 d后出现全身乏力、食欲减退、小便深黄。停用雷贝拉唑钠肠溶片。实验室检查:丙氨酸转氨酶401 U/L,天冬氨酸转氨酶314 U/L,碱性磷酸酶143 U/L,γ-L-谷氨酰转移酶359 U/L,总胆红素22.7μmol/L。给予保肝治疗。1周后复查,丙氨酸转氨酶40 U/L,天冬氨酸转氨酶15 U/L。 A 45-year-old male patient was given a rabeprazole sodium enteric-coated tablet 10 mg once daily for acid reflux. After 3 weeks because of increased symptoms to double their own medication. 3 days after the emergence of generalized weakness, loss of appetite, dark yellow urine. Disable rabeprazole sodium enteric-coated tablets. Laboratory tests: alanine aminotransferase 401 U / L, aspartate aminotransferase 314 U / L, alkaline phosphatase 143 U / L, γ-L-glutamyl transferase 359 U / L, total bilirubin 22.7 μmol / L. Give liver protection treatment. A week later, alanine aminotransferase 40 U / L, aspartate aminotransferase 15 U / L.