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目的 研究P16INK4a和CyclinD1 在子宫内膜癌中的表达及临床意义, 并探讨两者表达的相关性。方法 采用免疫组化SP法检测58例子宫内膜癌中P16INK4a和CyclinD1蛋白的表达。结果 P16INK4a、CyclinD1蛋白的阳性表达率分别为32 76%、51 72%, 两者的表达均与临床分期有关(P<0 05), P16INK4a蛋白表达还与组织学分级有关(P<0 05); P16INK4a和CyclinD1 蛋白的表达呈负相关(r=-0 428, P<0 01)。结论 P16INK4a和Cy clinD1与子宫内膜癌的发生和发展有关, 且两者存在协同作用。
Objective To study the expression and clinical significance of P16INK4a and CyclinD1 in endometrial carcinoma and to explore the correlation between them. Methods Immunohistochemical SP method was used to detect the expression of P16INK4a and CyclinD1 protein in 58 cases of endometrial carcinoma. Results The positive expression rates of P16INK4a and CyclinD1 protein were 32 76% and 51 72%, respectively. The expressions of P16INK4a and CyclinD1 protein were correlated with clinical stage (P <0.05). The expression of P16INK4a protein was also correlated with histological grade (P <0.05) ; P16INK4a and CyclinD1 protein expression was negatively correlated (r = -0 428, P <0.01). Conclusions P16INK4a and Cy clinD1 are associated with the occurrence and development of endometrial carcinoma, and they have synergistic effects.