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目的:观察苯磺酸氨氯地平和小剂量氢氯噻嗪治疗原发性轻、中度高血压的疗效。方法:将100例原发性轻、中度高血压患者随机分为2组,治疗组50例给予苯磺酸氨氯地平5mg/次,1/d;氢氯噻嗪12.5mg/次,1次/d,对照组50例只给苯磺酸氨氯地平5mg/次,1/d;在治疗8周和12周时评估治疗效果和药物的安全性。结果:治疗8周和12周时治疗组的总有效率均显著高于对照组(P均<0.05),2组均无明显不良反应,无显著差异。结论:苯磺酸氨氯地平和小剂量氢氯噻嗪治疗原发性轻、中度高血压比单用苯磺酸氨氯地平疗效更好。
Objective: To observe the efficacy of amlodipine besylate and low-dose hydrochlorothiazide in the treatment of primary mild to moderate hypertension. Methods: One hundred patients with primary mild to moderate essential hypertension were randomly divided into two groups. 50 cases in the treatment group were treated with amlodipine besylate 5 mg once daily, hydrochlorothiazide 12.5 mg once daily , 50 cases of the control group only to amlodipine besylate 5mg / time, 1 / d; in the treatment of 8 weeks and 12 weeks to assess the efficacy of the treatment and drug safety. Results: The total effective rate of the treatment group was significantly higher than that of the control group at 8 and 12 weeks (all P <0.05). No significant adverse reactions were found in the two groups. Conclusions: Amlodipine besylate and low-dose hydrochlorothiazide are more effective than amlodipine besylate in the treatment of primary mild to moderate hypertension.