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1954年,有些孕妇服用反应停后,娩出一些畸形胎儿,但当时并未引起人们的注意。及至60年代,孕妇服用该药后,更多的人娩出畸胎儿,这时,对孕妇服药可引起畸胎的事实,才引起全世界的重视。至畸药物对胎胚造成的损害,和用药时的妊娠期限、胎盘情况、遗传上的敏感性和母体的生理和病理状态有关。就中与妊娠期限关系最大。畸胎的发生,多在妊娠前3个月,因为这是受精卵相继分化和联合阶段,各系统尚未完全形成,最易受药物的影
In 1954, some pregnant women took some abnormal fetuses after taking the reaction, but at that time did not attract people’s attention. By the 1960s, more pregnant women took the medicine and gave birth to deformed teratomas. At this time, the fact that taking teratogenic drugs to pregnant women can only cause teratogenic problems has aroused the world’s attention. The damage to the embryos caused by the teratogen is related to the duration of pregnancy, the condition of the placenta, the genetic sensitivity and the physical and pathological status of the mother. In the relationship between the maximum duration of pregnancy. Teratogenesis, mostly in the first trimester of pregnancy, because this is the fertilized egg successive differentiation and joint stage, the system has not yet been fully formed, the most vulnerable to the shadow of the drug