目的 :观察高同型半胱氨酸 (Hcy)血症时小鼠组织金属硫蛋白 (MT)含量的变化。方法 :小鼠腹腔注射Hcy复制高Hcy血症模型。观察肝、心和肾组织的MT和丙二醛 (MDA)水平。结果 :肝、心和肾组织在Hcy组MT水平较对照组分别高 2 10 % (P <0 0 1)、133 % ((P <0 0 5 )和 6 0 % (P <0 0 1)。而丙二醛水平则分别高6 %、5 2 % (P <0 0 5 )和 6 9% (P <0 0 5 )。注射Hcy同时用超氧化物歧化酶 (SOD)处理的动物 ,肝、心和肾组织MT含量较Hcy组分别低 2 2 % (P <0 0 5 )、33 % (P <0 0 5 )和 13% (P >0 0 5 )。丙二醛含量则分别降低 2 4% (P <0 0 5 )、2 1% (P <0 0 5 )和 48% (P <0 0 1)。组织MT水平与MDA含量呈显著正相关。结论 :Hcy可能通过氧化应激诱导MT生成 Objective: To observe the changes of the content of metallothionein (MT) in mice with hyperhomocysteinemia. Methods: Hcy mice were injected intraperitoneally with Hcy hyperlipidemia model. The levels of MT and malondialdehyde (MDA) in liver, heart and kidney were observed. Results: The levels of MT in liver, heart and kidney in Hcy group were 210% (P <0.01), 133% (P <0.05) and 60% (P <0.01) higher than those in control group respectively While malondialdehyde levels were 6%, 52% (P <0 05) and 6 9% (P 0 05) respectively.While animals treated with Hcy and superoxide dismutase (SOD) The contents of MT in liver, heart and kidney were respectively 22% (P <0.05), 33% (P <0 05) and 13% (P 0 05) lower than those in Hcy group (P <0 05), 21% (P 0 05) and 48% (P 0 01) respectively.The MT level in the tissue was positively correlated with MDA content.Conclusion: Hcy may be oxidized by oxidation Stress-induced MT formation