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To summarize the treatment of acupuncture for polycystic ovary syndrome (PCOS) in view of scientific principles and basic and clinical data. The relevant literatures have been retrieved through MEDLINE computerization. A control trial of 3 cases indicates ovulation induction of acupuncture. Basic and clinical study verifies that electro-acupuncture (EA) can regulate the disturbed endocrinal, neuroendocrinal and sympathetic nervous systems in PCOS women[1]. It is known publicly that the high-class central activity is enhanced in human body after acupuncture and EA treatment because a series of neuropeptids are released, which is quite important in regulating central and peripheral nerve impulse of hypothalamus-pituitary-ovary (HPO) axis and hypothalamus-pituitary-adrenal (HPA) axis [2,3]. EA has been applied repeatedly to the women who are diagnosed definitely as PCOS and has been found long-term therapeutic effects on neuroendocrinal parameters and ovulation induction[4]. But, this study has not explained the mechanism of these efficacies. The basic study of laboratory evaluation on EA[5-9] indicates that the regulation of EA on ovary function is relevant with the adjustment of sympathetic nervous system activity.