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近已证明,小剂量促黄体生成激素释放激素(LRH)治疗促性腺激素水平低下的原发性或继发性闭经妇女,有诱导排卵的效果.由于电脑调控微型灌注泵研制成功,使这种间歇输注LRH的方法能用于临床.本文作者报告采用Zyklomat电脑调控微型泵,间歇输注小剂量LRH,治疗7例继发性闭经妇女,旨在促进卵泡成熟和排卵.7例治疗对象的年龄为22～32岁,继发性闭经时间为2.5～11年.患者血清PRL水平和蝶鞍摄片均正常.甲状腺和肾上腺功能无异常.孕酮撤血试验阴性,提示内源性雌激素水平低下.用氯菧酚促排卵无效.血清促性腺激素水平正常或低下.
It has been demonstrated that low dose of luteinizing hormone releasing hormone (LRH) treatment of gonadal hormones in patients with primary or secondary amenorrhea induced ovulation results due to the computer-controlled micro-perfusion pump developed to make this The method of intermittent infusion of LRH can be used clinically.This paper reports the use of Zyklomat microcomputer-controlled micro-pump, intermittent infusion of small doses of LRH, treatment of 7 cases of secondary amenorrhea women, to promote follicular maturation and ovulation .7 cases of treatment Aged 22 to 32 years, secondary amenorrhea time is 2.5 to 11 years.Patients with serum PRL levels and sella radiographs are normal.Normal thyroid and adrenal function.Progesterone withdrawal test was negative, suggesting that endogenous estrogen Low level.Using chlorophenol ovulation ineffective serum gonadotropin levels were normal or low.