目的:探讨湿润后米索前列醇联合双异丙酚在无痛人工流产术中的临床效果。方法:选择接受早期无痛人工流产手术的120例早孕妇女随机分为观察组和对照组各60例,观察组和对照组在术前30 min静脉注射双异丙酚,观察组给予阴道后穹窿放置湿润后米索前列醇400μg,对照组给予常规阴道后穹窿放置米索前列醇片400μg,观察两组的宫颈松弛情况、子宫收缩情况、术中出血量、手术时间等。结果:观察组宫颈松弛情况、子宫收缩情况、术中出血量、手术时间均显著优于对照组,差异有统计学意义(P<0.05)。结论:湿润后米索前列醇和双异丙酚在无痛人工流产术前的联合应用可促进宫颈扩张、增强子宫收缩、术中出血显著减少,有效提高手术质量并减少手术并发症,具有良好的推广应用价值。 Objective: To investigate the clinical effect of misoprostol combined with propofol in painless artificial abortion. Methods: A total of 120 early pregnancy women who underwent early painless abortion were randomly divided into observation group and control group, with 60 cases in each group. The propofol group and the control group were given propofol 30 minutes before the operation. The observation group was given vaginal fornix 400μg of misoprostol was placed in the control group and 400μg of misoprostol was placed in the vaginal fornix of the control group. Cervical relaxation, uterine contractions, intraoperative blood loss, operation time and so on were observed. Results: The cervical relaxation, uterine contraction, intraoperative blood loss and operation time in the observation group were significantly better than those in the control group (P <0.05). Conclusions: The combined application of misoprostol and propofol before painless artificial abortion can promote cervical dilatation, increase uterine contractions, significantly reduce intraoperative bleeding, effectively improve the quality of operation and reduce the complications of surgery, and have good Promote the value of application.