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目的:探讨转化生长因子β受体(TGFβR)Ⅰ型及Ⅱ型在慢性鼻-鼻窦炎、鼻息肉及正常下鼻甲组织中表达的差异性,以及Ⅰ、Ⅱ型受体在慢性鼻窦炎、鼻息肉发病机制中可能的作用。方法:采用免疫组织化学方法检测TGFβRⅠ、TGFβRⅡ在25例慢性鼻-鼻窦炎、21例鼻息肉、17例下鼻甲组织中的表达,并比较TGFβRⅠ、TGFβRⅡ在慢性鼻-鼻窦炎、鼻息肉、正常下鼻甲组织中表达的差异。结果:TGFβRⅠ、TGFβRⅡ表达的平均灰度值在正常下鼻甲黏膜分别为175.78±7.06、165.00±1.79;在慢性鼻-鼻窦炎组织中分别为147.33±8.15、147.77±4.62;而在鼻息肉组织中分别为125.91±11.26、129.82±1.46。慢性鼻-鼻窦炎及鼻息肉组织中TGFβRⅠ、TGFβRⅡ的表达均比正常下鼻甲黏膜中的表达高,均差异有统计学意义(均P<0.01);且TGFβRⅠ、TGFβRⅡ在鼻息肉组织中的表达比在慢性鼻-鼻窦炎病变黏膜中的表达高,均差异有统计学意义(均P<0.01)。结论:TGFβRⅠ、TGFβRⅡ在慢性鼻-鼻窦炎、鼻息肉组织中具有不同的表达水平及分布特点,提示其可能在慢性鼻-鼻窦炎、鼻息肉的发生发展过程中发挥不同的作用。
Objective: To investigate the difference of expression of TGFβR Ⅰ and Ⅱ in chronic rhinosinusitis, nasal polyps and normal inferior turbinate tissue, and to explore the role of type Ⅰ and Ⅱ receptors in chronic sinusitis, nasal Possible role of polyps in pathogenesis. Methods: Immunohistochemistry was used to detect the expressions of TGFβRⅠ and TGFβRⅡ in 25 cases of chronic rhinosinusitis, 21 cases of nasal polyps and 17 cases of inferior turbinate tissues. The expressions of TGFβRⅠ and TGFβRⅡ in chronic rhinosinusitis, nasal polyps, Differences in expression in inferior turbinate tissue. Results: The average gray value of TGFβRⅠ and TGFβRⅡ expression in the normal inferior turbinate mucosa were 175.78 ± 7.06 and 165.00 ± 1.79, respectively, and 147.33 ± 8.15 and 147.77 ± 4.62 in the chronic rhinosinusitis tissues respectively. However, Respectively 125.91 ± 11.26,129.82 ± 1.46. The expression of TGFβRⅠ and TGFβRⅡ in chronic rhinosinusitis and nasal polyps was higher than that in normal inferior turbinate mucosa (all P <0.01), and the expression of TGFβRⅠ and TGFβRII in nasal polyps Which was higher than that in chronic nasosinusitis mucosa (all P <0.01). CONCLUSION: TGFβRⅠ and TGFβRⅡ have different expression levels and distribution in chronic rhinosinusitis and nasal polyps, suggesting that they may play different roles in the development and progression of chronic rhinosinusitis and nasal polyps.