论文部分内容阅读
在全球范围内,肺癌的死亡率居各种恶性肿瘤之首。目前诊断肺癌的常规方法难以诊断早期肺癌,不能有效提高5年存活率。呼气中挥发性有机物(VOCs)与人体新陈代谢过程密切相关,通过呼气检测肺癌以及其他疾病的研究已成为热点。由于呼气检测方法具有非侵入性、无痛苦、不昂贵等优点,有望成为检测早期肺癌的新方法。本文综述了呼气中的VOCs与人体新陈代谢的关系、影响人体呼气中VOCs浓度的因素、呼气采集方法以及呼气检测肺癌的分析技术研究进展。探讨了呼气诊断早期肺癌仍存在的问题和未来的应用前景。
Globally, lung cancer ranks first among all malignancies. The current diagnosis of lung cancer is difficult to diagnose early lung cancer, can not effectively improve the 5-year survival rate. Volatile organic compounds (VOCs) in exhalation are closely related to human metabolism, and research on lung cancer and other diseases through exhalation has become a hot spot. As the breath detection method has the advantages of non-invasive, painless, inexpensive, is expected to become a new method of detecting early lung cancer. This review summarizes the relationship between VOCs in exhalation and human metabolism, the factors influencing the concentration of VOCs in human exhaled breath, the methods of breath acquisition and the research progress in the analytical techniques of exhaled breath detection of lung cancer. Exploring the problems of expiratory diagnosis of early lung cancer and future application prospects.