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本文报道采用高剂量顺铂(DDP)动脉灌注“双路”化疗治疗8例经病理学证实的中晚期恶性肿瘤,其中原发或转移性肝癌5例,Ⅲ-Ⅳ期乳腺癌3例。每例进行1—2疗程,DDP剂量第一疗程单一用药80—100mg/m~2。第二疗程120—150mg/m~2加用硫代硫酸钠(STS)解毒。DDP治疗前后水化甘露醇利尿。单用DDP动脉灌注时,血清肌酐一过性升高,而DDP+STS时未见明显改变。结果:5例肝癌中:1例完全缓解,3例部份缓解,1例稳定,3例乳癌均部份缓解。
This article reported the use of high-dose cisplatin (DDP) arterial perfusion “two-way” chemotherapy in the treatment of 8 cases of pathologically confirmed advanced and advanced malignant tumors, including primary or metastatic liver cancer in 5 cases, III-IV breast cancer in 3 cases. Each case was treated with 1-2 courses of treatment. The first course of DDP dose was 80-100 mg/m~2. The second course of treatment 120-150mg/m~2 plus sodium thiosulfate (STS) detoxification. Hydration of mannitol diuretic before and after DDP treatment. In the arterial perfusion with DDP alone, serum creatinine increased transiently, but there was no significant change in DDP+STS. Results: Of the 5 cases of liver cancer, 1 had complete remission, 3 had partial remission, 1 had stable, and 3 had partial remission.