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抗心律失常药物是目前开展血药监测的一个重要方面,由于奎尼丁的治疗安全范围小,个体差异大,不良反应多,治疗的有效血浓度为2～7μg·ml~(-1),8μgml~(-1)即可产生中毒症状,治疗血浓度与中毒血浓度较接近,因而受到重视。为了给临床医生提供奎尼丁个体化治疗的合理给药方案,保证用药安全有效,开展奎尼丁血浓度监测确有必要。 有关血中奎尼了浓度的测定法,国外报道有多种(色谱法、荧光分光光度法、免疫化学法等),国内有杨雅平报道血清中微量硫酸奎尼丁的荧光分光光度测定法,采用进口荧光分光光度计,其价格昂贵,不为一
Antiarrhythmic drugs is currently an important aspect of blood drug monitoring. Because quinidine has a small therapeutic safety range, large individual differences and many adverse reactions, the effective blood concentration for treatment is 2 to 7 μg · ml -1, 8μgml ~ (-1) can produce symptoms of poisoning, the treatment of blood concentration and the concentration of poisoning blood closer to, which received the attention. In order to provide clinicians with a rational drug regimen for individualized treatment of quinidine and to ensure that the drug is safe and effective, the monitoring of quinidine blood concentration is indeed necessary. Quinidine concentration in the blood of the assay, there are many foreign reports (chromatography, fluorescence spectrophotometry, immunochemistry, etc.), the domestic Yang Ya-ping trace serum trace quinidine sulfate spectrophotometry, the use of Import fluorescence spectrophotometer, its expensive, not one