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胰管结石合井胰腺癌是较少见的疾病，术前不易确诊。本组５例中术前确诊仅２例，占该院同期收治胰管结石病例的１７．２％。其临床特点是：①男性多见；②有慢性酒精性胰腺炎病史，并发糖尿病亦多见；③病程较长，主要表现为上腹持续疼痛，顽固背心痛，纳差，腹泻，消瘦，发生黄疽者较少。诊断时应注意：①对有胰管结石患者，当其慢性胰腺炎症状短期内持续加重，伴纳差、消瘦明显时，应警惕合并胰腺癌的可能性；②应采用多种影像学和肿瘤标记物如ＣＡ１９－９、ＣＥＡ、乳铁蛋白检查，有助诊断；③术中细致探查，对可疑结节应作冰冻活检。
Pancreatic duct stones and pancreatic cancer are rare diseases that are not easily diagnosed before surgery. Of the 5 patients in this group, only 2 cases were diagnosed before surgery, accounting for 17.2% of cases of pancreatic duct stones in the same period. Its clinical features are: 1 more common in men; 2 have a history of chronic alcoholic pancreatitis, concurrent diabetes is also more common; 3 longer duration, mainly for the upper abdomen continued pain, stubborn vest pain, anorexia, diarrhea, weight loss, the occurrence of There are fewer jaundice. The diagnosis should pay attention: 1 patients with pancreatic duct stones, when the chronic symptoms of chronic pancreatitis continue to increase, with acne, weight loss is obvious, should be alert to the possibility of pancreatic cancer; 2 should use a variety of imaging and tumor Markers such as CA19-9, CEA, lactoferrin examination, help diagnosis; 3 careful exploration of surgery, suspicious nodules should be frozen biopsy.