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目的:探讨江苏省苏南地区急性冠脉综合征(ACS)患者危险因素的分布特点及其与预后的关系。方法:用中位数来计算苏南地区ACS患者危险因素的分布情况,并分析危险因素个数与预后的关系。结果:苏南地区ACS患者危险因素个数的中位数为5;在单个危险因素亚组中,年龄>5岁、高密度脂蛋白(HDL)<40 mg.dl-1(男性)或<50 mg.dl-1(女性)、高血压病、糖尿病、甘油三酯(TG)>150 mg.dl-1、前驱糖尿病的患者较无此类因素者危险因素个数的中位数之比为6∶5;而低密度脂蛋白(LDL)>70 mg.dl-1亚组中位数之比为5∶4;男性、早发冠心病家族史亚组中位数之比分别为6∶4、7∶5;吸烟、肥胖、CRP>2 mg.L-1亚组中位数之比为5∶5。所有患者危险因素个数从2～8,随着危险因素个数的增加,患者中远期主要不良心血管事件的发生率从19.3%增加到38.6%。结论:在本次调查的苏南地区人群中,男性、早发冠心病家族史将导致该患者总体危险因素个数增多,而年龄>65岁、HDL<40 mg.dl-1(男性)或<50 mg.dl-1(女性)、LDL>70 mg.dl-1、高血压病、糖尿病、TG>150 mg.dl-1、前驱糖尿病亦是危险因素增加的重要因素;同时随着危险因素个数的增加,患者发生心脑血管意外的风险相应增加。
Objective: To investigate the distribution of risk factors in patients with acute coronary syndrome (ACS) and its relationship with prognosis in southern Jiangsu province. Methods: The median was used to calculate the distribution of risk factors in patients with ACS in southern Jiangsu Province, and to analyze the relationship between the number of risk factors and prognosis. Results: The median number of risk factors for ACS patients in southern Jiangsu was 5. In the subgroup of single risk factors, patients aged> 5 years, high density lipoprotein (HDL) <40 mg.dl-1 (male) or < 50 mg.dl-1 (female), hypertension, diabetes mellitus, triglyceride (TG)> 150 mg.dl-1, the median of the number of risk factors in patients with prediabetes compared with no such factors (6: 5), while the median of low-density lipoprotein (LDL)> 70 mg.dl-1 subgroup was 5: 4. The median ratios of male patients with premature coronary heart disease family history subgroup were 6 : 4,7: 5; smoking, obesity, CRP> 2 mg.L-1 subgroup median ratio of 5: 5. The number of risk factors for all patients ranged from 2 to 8. As the number of risk factors increased, the prevalence of major adverse cardiovascular events in patients increased from 19.3% to 38.6%. CONCLUSIONS: In the southern part of Jiangsu Province, male, family history of premature coronary heart disease will lead to an increase in the overall risk factors for this population. However, those aged> 65 years, HDL <40 mg.dl-1 (male) or <50 mg.dl-1 (female), LDL> 70 mg.dl-1, hypertension, diabetes, TG> 150 mg.dl-1, prediabetes is also an important risk factor for increased risk; at the same time with the risk The increase in the number of factors, patients with cardiovascular and cerebrovascular accident risk increased accordingly.