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目的:了解胃肠多肽受体的表达在胰腺癌发生过程中的重要意义。方法:用储磷放射自显影显示和比较正常胰腺(n=10)及胰腺导管癌(n=12)的胆囊收缩素(CCK)、蛙皮素(BBS)、胰泌素、肠血管活性多肽(VIP)及生长抑素(SST)受体。结果:与正常胰腺比较,胰腺癌细胞上的多肽受体表达发生了很大变化。存在于正常胰腺腺泡细胞上的CCK、BBS、胰泌素受体在胰腺癌细胞上明显减少或消失。反之,在多数病例的胰腺癌细胞上检测到在正常胰腺不能显出的肠血管活性多肽及生长抑素受体。结论:本研究为胰腺癌的激素治疗提供了有价值的依据。
Objective: To understand the significance of gastrointestinal polypeptide receptor expression in the development of pancreatic cancer. METHODS: Cholecystokinin (CCK), bombesin (BBS), secretin, and intestinal vasoactive peptides of normal pancreas (n=10) and pancreatic ductal carcinoma (n=12) were visualized and compared using stored phosphorus autoradiography. (VIP) and somatostatin (SST) receptors. Results: The expression of polypeptide receptors on pancreatic cancer cells was greatly changed compared with normal pancreas. The CCK, BBS, and secretin receptors present on normal pancreatic acinar cells were significantly reduced or disappeared on pancreatic cancer cells. In contrast, intestine vasoactive peptides and somatostatin receptors that were not found in normal pancreas were detected on pancreatic cancer cells in most cases. Conclusion: This study provides a valuable basis for hormone therapy of pancreatic cancer.