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目的 :观察慢性心力衰竭 (CHF)患者左右心室收缩同步性差异 ,心电图、左室几何形态、左室收缩功能的变化。探讨双室收缩差异的发生率、双室收缩不同步与左室收缩功能、左心室几何构型、二尖瓣反流的关系。方法 :选择 2 2例CHF患者 (CHF组 ) ,NYHA分级Ⅱ～Ⅲ级 ,均符合Framingham心力衰竭诊断标准 ;健康体检者 (对照组 ) 16例 ,进行心电图、超声心动图测量、平衡状放射性核素心室造影检查。获得QRS间期、P R间期、左心室几何构型收缩期及舒张期参数 (Gibson’s指数、Cole’s指数、面积长度指数 )、二尖瓣反流程度、左和右心室功能参数、全心室的相角程、半高宽。结果 :与对照组相比CHF患者的心电图 (均P <0 .0 5 )、心脏几何构型 (均P <0 .0 5 )、左室射血分数 (LVEF)明显不同 (P <0 .0 1)、位相分析参数 (P <0 .0 1)存在着明显异常 ;77%CHF患者存在着室间非同步收缩 ,这些患者具有较低的LVEF及较重的二尖瓣反流程度 ;室间非同步收缩与左心功能呈明显负相关(r =- 0 .5 5 ,P <0 .0 5 ) ,与二尖瓣反流程度呈明显正相关 (r =0 .5 6 8,P <0 .0 5 ) ,与左心室舒张期几何形态有一定的相关性 (r =0 .5 32 ,P <0 .0 5、r =0 .5 32 ,P <0 .0 5 )。结论 :室间非同步收缩的形成与左心室舒张期几何形态及二尖瓣反流的
Objective: To observe the differences of left ventricular systolic synchrony, electrocardiogram, left ventricular geometry and left ventricular systolic function in patients with chronic heart failure (CHF). To investigate the incidence of binocular differences, the relationship between binocular systolic asynchrony and left ventricular systolic function, left ventricular geometry and mitral regurgitation. Methods: Twenty-two CHF patients (CHF group) and NYHA class Ⅱ-Ⅲ were selected. All of them were in accordance with the diagnostic criteria of Framingham heart failure. Sixteen healthy subjects (control group) had ECG, echocardiography, balanced radionuclide Vegetarian ventriculography. The QRS interval, PR interval, systolic and diastolic parameters (Gibson’s index, Cole’s index, area length index), mitral regurgitation, left and right ventricular function parameters, Angle range, half-width. Results: The electrocardiogram (P <0. 05), cardiac geometry (all P <0. 05) and left ventricular ejection fraction (LVEF) were significantly different in CHF patients compared with the control group (P <0. There was a significant abnormality in the phase analysis parameters (P <0. 01). There was an interventricular asynchrony contraction in 77% of CHF patients. These patients had low LVEF and severe mitral regurgitation. There was a significant negative correlation between interventricular asynchrony and left ventricular function (r = -0.55, P <0.05), and positively correlated with the degree of mitral regurgitation (r = 0.556, P <0.05), and left ventricular diastolic geometry has a certain correlation (r = 0.532, P <0.05, r = 0.532, P <0.05). CONCLUSIONS: The formation of nonsynchronized astigmatism and the left ventricular diastolic geometry and mitral regurgitation