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目的探讨载脂蛋白B(ApoB)与T2DM患者UAER及脂代谢异常的关系。方法纳入192例T2DM患者(T2DM组)及60名健康对照者(NC组),比较两组脂代谢情况。结果 T2DM组ApoB高于NC组[(1.00±0.30)vs(0.92±0.32)mmol/L]。两组ApoB与LDL-C均有相关性,但T2DM组相关性低于NC组。当LDL-C<2.6mmol/L时,仍有34.4%的T2DM患者ApoB>0.9g/L。结论 ApoB是T2DM患者出现UAlb的独立危险因素之一,与T2DM患者UAER增加有关。与LDL-C、TC比较,ApoB更能说明T2DM脂代谢异常。
Objective To investigate the relationship between apolipoprotein B (ApoB) and UAER and lipid metabolism abnormalities in T2DM patients. Methods A total of 192 patients with T2DM (T2DM group) and 60 healthy controls (NC group) were enrolled in this study. Lipid metabolism was compared between the two groups. Results The ApoB in T2DM group was higher than that in NC group [(1.00 ± 0.30) vs (0.92 ± 0.32) mmol / L]. Both ApoB and LDL-C were correlated, but the correlation between T2DM group and NC group was lower than that of NC group. When LDL-C <2.6mmol / L, 34.4% of T2DM patients still had ApoB> 0.9g / L. Conclusion ApoB is one of the independent risk factors of UAlb in T2DM patients, which is related to the increase of UAER in T2DM patients. Compared with LDL-C, TC, ApoB can better explain T2DM lipid metabolism.