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目的:分析青海地区宫颈非典型鳞状细胞联合高危型人乳头瘤病毒检测结果,以指导青海地区对非典型细胞(ASC-US)的临床处理。方法:对2009年1月—2013年4月我院妇产科行宫颈液基细胞学为不明确意义的非典型鳞状细胞的1 000例患者,再行第二代杂交捕获(HC2)检测高危型人乳头瘤病毒(HR-HPV)DNA含量,并进行阴道镜检查及活检,分析其结果之间的关系。结果:1 000例ASC-US的活检病理结果为宫颈上皮内瘤变176例(17.6%),宫颈鳞状细胞癌2例(0.2%),宫颈腺癌2例(0.2%);1 000例ASC-US中HR-HPV阳性326例(32.6%),其中宫颈高级别上皮内瘤样病变(CIN)甚至宫颈鳞状细胞癌70例(21.5%),宫颈腺癌2例(0.6%);674例HC2阴性的患者病理活检结果 19例(2.8%)为低级别宫颈上皮内瘤样病变,无高级别宫颈上皮内瘤样病变及以上病变。结论:宫颈液基细胞学ASC-US提示宫颈病变的存在,而高危型人乳头瘤病毒(HR-HPV)检测可以作为ASC-US患者是否需要立即行阴道镜检查及活检的一个预测指标。
Objective: To analyze the results of cervical atypical squamous cell and high-risk human papillomavirus in Qinghai to guide the clinical treatment of atypical cells (ASC-US) in Qinghai. Methods: From January 2009 to April 2013 in our hospital obstetrics and gynecology hospital cervical liquid-based cytology of atypical squamous cell of unknown significance in 1 000 patients, followed by second-generation hybridization capture (HC2) test High-risk human papillomavirus (HR-HPV) DNA content, and colposcopy and biopsy, analysis of the relationship between the results. Results: The biopsy results of 1 000 cases of ASC-US were 176 cases (17.6%) of cervical intraepithelial neoplasia, 2 cases of cervical squamous cell carcinoma (0.2%), 2 cases of cervical adenocarcinoma (0.2%) and 1 000 cases There were 326 cases (32.6%) of HR-HPV positive in ASC-US, including 70 cases (21.5%) with cervical intraepithelial grade high grade intraepithelial neoplasia (CIN) or cervical squamous cell carcinoma, 2 cases (0.6%) with cervical adenocarcinoma; Among the 674 HC2-negative patients, 19 cases (2.8%) had low-grade cervical intraepithelial neoplasia without high-grade cervical intraepithelial neoplasia and the above pathological findings. CONCLUSIONS: Cervical LC-ASC suggests the presence of cervical lesions, whereas high-risk human papillomavirus (HR-HPV) tests may be used as a predictor of colposcopy and biopsy in ASC-US patients.