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目的探究血清中血浆骨膜蛋白(P e r i o s t i n)、血管内皮生长因子(VEGF)、内皮素-1(ET-1)含量检测在(Acute coronary syndromes,ACS)病情评估中应用价值。方法选取我院2014年4月~2016年3月ACS患者96例作为研究组,依据疾病类型分为不稳定型心绞痛(UA)49例与急性心肌梗死(AMI)47例,另选同期体检健康者46例作为对照组,各组均应用酶联免疫吸附法检测血清ET-1、Periostin、VEGF含量,分析比较各组ET-1、Periostin、VEGF含量。结果研究组ET-1、Periostin、VEGF含量均高于对照组,差异具有统计学意义(P<0.05);AMI患者ET-1、Periostin、VEGF含量均高于UA患者,差异具有统计学意义(P<0.05)。结论血清中ET-1、Periostin、VEGF含量检测对评估ACS患者病情具有较高应用价值。
Objective To investigate the value of detection of Pterytium, Vascular Endothelial Growth Factor (VEGF) and Endothelin-1 (ET-1) in the serum of acute coronary syndromes (ACS). Methods A total of 96 ACS patients from April 2014 to March 2016 in our hospital were selected as study group. According to the type of disease, 49 patients with unstable angina pectoris (UA) and 47 patients with acute myocardial infarction (AMI) were enrolled. 46 as control group. The levels of ET-1, Periostin and VEGF in serum were detected by enzyme-linked immunosorbent assay (ELISA). The levels of ET-1, Periostin and VEGF in each group were compared. Results The levels of ET-1, Periostin and VEGF in the study group were significantly higher than those in the control group (P <0.05). The levels of ET-1, Periostin and VEGF in AMI patients were significantly higher than those in UA patients P <0.05). Conclusion The serum levels of ET-1, Periostin and VEGF are of high value in the evaluation of ACS patients.